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estimate

Can I run Qwen2.5 72B on an RTX 5080?

No: needs ~47.1 GB, this card has ~15.4 GB usable (estimate)

Can I run Qwen2.5 72B on an RTX 5080? No: needs ~47.1 GB, this card has ~15.4 GB usable (estimate). About 47.1 GB at Q4_K_M (estimate).

Updated . The later of the hardware price date and the formula date.

Qwen2.5 72B on RTX 5080, formula estimate
QuantContextWeightsKVOverheadTotalUsableFitEst. tok/s
Q4 Q4_K_M8,192 tokens43.6 GB estimate2.7 GB estimate0.8 GB estimate47.1 GB estimate15.4 GB estimateno—
Q5 Q5 (~0.71 bytes/param)8,192 tokens51.6 GB estimate2.7 GB estimate0.8 GB estimate55.1 GB estimate15.4 GB estimateno—
Q8 Q88,192 tokens77.8 GB estimate2.7 GB estimate0.8 GB estimate81.3 GB estimate15.4 GB estimateno—
FP16 FP168,192 tokens145.4 GB estimate2.7 GB estimate0.8 GB estimate148.9 GB estimate15.4 GB estimateno—
Q4, longer context32,768 tokens43.6 GB estimate10.7 GB estimate0.8 GB estimate55.2 GB estimate15.4 GB estimateno—

Formula estimate, not a benchmark. Method →

Cheapest catalog option that fits at Q4

Mac mini M4 Pro 64GB, catalog price, €1,890, dated 2026-10-16. No buy link.

This hardware

$1,468€1,311

new (lowest in-stock EU)

price as of 17 Oct 2026

GPU PRIX

Lowest in-stock board in the table on 17 Oct 2026: €1,311, ASUS Prime GeForce RTX 5080, in stock. The same page's header current low was €1,328, last updated Oct 17, 2026. 16 GB GDDR7 and 360 W total graphics power are on NVIDIA's RTX 5080 spec page (https://www.nvidia.com/en-us/geforce/graphics-cards/50-series/rtx-5080/). 960 GB/sec is the RTX 5080 column on NVIDIA's GeForce compare page (https://www.nvidia.com/en-us/geforce/graphics-cards/compare/). The product spec table that was fetched did not print a GB/s row.

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Qwen2.5 72B on RTX 5080

[![Qwen2.5 72B Q4 on RTX 5080: ✗ · needs 47.1 GB (estimate)](https://localllmrig.com/badge/qwen2.5-72b/rtx-5080.svg)](https://localllmrig.com/can-i-run/qwen2.5-72b/rtx-5080?utm_source=badge)

Questions

Can I run Qwen2.5 72B on an RTX 5080?
No: needs ~47.1 GB, this card has ~15.4 GB usable (estimate).
How much memory does Qwen2.5 72B need at Q4?
About 47.1 GB at 8,192 tokens (estimate): 43.6 GB weights, 2.7 GB KV cache, 0.8 GB overhead.
How fast is Qwen2.5 72B on RTX 5080 (estimate)?
No tokens-per-second estimate. The Q4 fit is not full and not offload, so this page leaves speed blank.
Qwen2.5 72B on RTX 5080 (estimate) · localLLMrig